The correct sequence for configuring TLS profiles in IBM API Connect follows the platform's hierarchical structure and component dependencies.

1. Organization: The configuration starts at the highest level, which is the provider Organization. This entity acts as a container for all other components like Catalogs, APIs, and Products.
2. Catalog: Within an Organization, you create a Catalog, which serves as a staging target for APIs. Key configurations, including the TLS profiles for the associated API gateway, are managed at this level.
3. Portal: The Developer Portal is a service associated with a specific Catalog. Its TLS profile is configured within the parent Catalog's settings to secure the portal's website.
4. Space: A Space is a subdivision within a Catalog. Official documentation states that before you can enable and use Spaces, the parent Catalog and its associated Developer Portal must already be configured. Therefore, Space configuration is the final step in this sequence.

IBM API Connect v10.x Documentation, "Administering Catalogs": This source details the API Connect hierarchy, stating: "A Catalog is created within a provider organization... A Space is a subdivision of a Catalog." This establishes the Organization -> Catalog -> Space sequence.

IBM API Connect v10.x Documentation, "Securing the Developer Portal": The procedure for assigning a TLS profile to the Portal website explicitly shows that this action is performed within the settings of a specific Catalog. This confirms that Portal configuration is dependent on and occurs after the Catalog is established.

IBM API Connect v10.x Documentation, "Using syndication in IBM API Connect": This document clarifies the dependency between the Portal and Spaces. It states, "Before you can enable Spaces in a Catalog, you must have configured the user registries for the Catalog and the associated Developer Portal." This confirms that Portal configuration must precede Space configuration.