For a specific image file, C makes the most sense since Defender for Endpoint can use file hashes to directly block it. I saw something similar in practice exams and the docs always mention hash-based indicators for targeting individual files. Only reason I'd hesitate is if they mentioned domain-wide threats, but that's not the case here. Anyone disagree?
File hash indicator is the way to go here, C. Blocking the specific hash is precise and stops just that malicious image, not everything from a domain. Pretty sure this matches how Defender for Endpoint works with file-based IoCs. Correct me if I'm wrong but C seems spot on.