VMware Horizon is a solution that delivers Windows and Linux virtual desktops and published
applications to end users from centralized servers.
One of the best practices for delivering Microsoft Office 365 in VMware Horizon is to disable Cached
Exchange Mode for Outlook3. This can improve performance and reduce storage requirements.
There are different profile management toolsets that can be used with Office 365 and VMware
Horizon. One of them is Horizon Persona Management4, which is a feature that synchronizes user
profiles with a remote repository and provides a personalized desktop experience.
Another option is FSLogix Profile Management5, which is a Microsoft solution that enhances Office
365 performance in non-persistent VDI environments by redirecting user profiles to virtual disks.
https://techzone.vmware.com/resource/best-practices-delivering-microsoft-office-365-vmwarehorizon