The calculation involves two steps. First, determine the total volume of the intravenous fluid (IVF) administered over 24 hours. At a rate of 125 mL/hour, the total volume is 125 mL/hour × 24 hours = 3000 mL. Second, calculate the amount of dextrose in this volume. A "Dextrose 5%" solution means it contains 5 grams of dextrose per 100 mL of solution (% w/v). Using this concentration, the total amount of dextrose is (5 g / 100 mL) × 3000 mL = 150 grams. The potassium chloride content is not relevant to this specific question.

A. 300gm: This would be the correct amount if the solution was Dextrose 10%, not 5%.

B. 500gm: This is an incorrect calculation, possibly confusing the percentage with the final amount in grams.

C. 50gm: This represents the amount of dextrose in only 1000 mL (1 L) of the solution, not the total 24-hour volume of 3000 mL.

E. 200gm: This is a mathematical error and does not correspond to the given concentration and infusion rate.

1. Allen

L. V.

Jr. (2018). Ansel's Pharmaceutical Dosage Forms and Drug Delivery Systems (11th ed.). Wolters Kluwer. Chapter 6

"Pharmaceutical Calculations

" Section on Percentage Strength

p. 115. This section defines percentage weight-in-volume (% w/v) as grams of a constituent in 100 mL of solution.

2. University of Washington School of Pharmacy. (n.d.). Pharm 558: Pharmaceutical Calculations - Intravenous Flow Rates. Course materials. These materials detail the standard method for calculating the total amount of a drug infused over a specific period by first determining the total volume (Rate × Time) and then multiplying by the drug concentration.

3. Zatz

J. L.

& Teixeira

M. G. (2005). Pharmaceutical Calculations (4th ed.). Wiley-Interscience. Chapter 5

"Percentage

Ratio Strength

and Other Expressions of Concentration

" pp. 67-69. This chapter provides examples for calculating the quantity of an active ingredient in a specified volume of a liquid when the concentration is expressed as a percentage.